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Identification of FOXP1 and SNX2 as novel ABL1 fusion partners in acute lymphoblastic leukaemia.

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Br J Haematol2011PMID 21391972stubpubmedProvenance
Source
PubMed
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Run
ING-CIVIC-20260908-000001
Published

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Linked entities

Linked entities (6)

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Validated 6

Curated evidence

Evidence citing this paper (2)

civicProvenance
Source
CIViC — Clinical Interpretation of Variants in Cancer
Dataset
CIViC evidence items
Version
civic-2026-09-08
Retrieved
Sep 8, 2026
Layer
normalized (units and labels harmonized; values unchanged)
Evidence
expert curation
License
CC0 1.0
PMID
21391972
Run
ING-CIVIC-20260908-000001
Open at source CuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.
TherapyCancerTypeLevelDirection · significanceRating (1–5)StatusEvidenceSource
ABL1 Fusion1
ImatinibB Lymphoblastic Leukemia/LymphomaCURATED_BROADERPredictiveCSupports Reduced Sensitivity1accepted
EID7254

In a 29-year-old man with pre B-cell ALL, the t(5;9)(q23;q34) [SNX2-ABL1] was identified. The SNX2-ABL1 fusion, which joins the N-terminal domain of SNX2 without the PX domain to ABL1 exon 4, was dete… (full text at CIViC)

PMID 21391972 · Ernst et al., 2011 · Open in CIViC

civic
ABL1 Fusion1
(oncogenic)B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-LikeOncogenicCSupports Oncogenicity2accepted
EID7253

In a 16-year old Caucasian female with B-lymphoblastic leukemia (B-ALL), the t(3;9)(p12;q34) was identified by cytogenetic studies. 5'RACE PCR detected the in-frame FOXP1::ABL1 (exon 19::exon 4) fusio… (full text at CIViC)

PMID 21391972 · Ernst et al., 2011 · Open in CIViC

civic