Publication
Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (8)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 8
- cancerBladder Carcinomacivic_curation1.00
- drugDovitinibcivic_curation1.00
- drugPD173074civic_curation1.00
- drugTyrosine Kinase Inhibitor SU5402civic_curation1.00
- geneFGFR1civic_curation1.00
- geneFGFR3civic_curation1.00
- variantFGFR1 Expressioncivic_curation1.00
- variantFGFR3 Overexpressioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21119661
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FGFR1 Expression1 | ||||||||
| Dovitinib + PD173074Substitutes | Bladder Carcinoma | Predictive | D | Supports Sensitivity Response | 2 | accepted | EID801One urothelial cell line (JMSU1) with high expression of FGFR1 was sensitive to treatment with FGFR inhibitors (SU5402, TKI258 or PD173074). IC50 values for PD173074 and TKI-258 (Dovitinib) were in n… (full text at CIViC) PMID 21119661 · Lamont et al., 2011 · Open in CIViC | civic |
| FGFR3 Overexpression1 | ||||||||
| Dovitinib + PD173074 + Tyrosine Kinase Inhibitor SU5402Substitutes | Bladder Carcinoma | Predictive | D | Supports Sensitivity Response | 3 | accepted | EID803The effects of FGFR inhibitors (PD173074, TKI-258 and SU5402) in bladder carcinoma cell lines were related to FGFR3 (and/or FGFR1) expression. PMID 21119661 · Lamont et al., 2011 · Open in CIViC | civic |