Publication
Cancer-associated p53 tetramerization domain mutants: quantitative analysis reveals a low threshold for tumor suppressor inactivation.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (6)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 6
- geneTP53civic_curation1.00
- variantTP53 L330Pcivic_curation1.00
- variantTP53 L330Rcivic_curation1.00
- variantTP53 L344Pcivic_curation1.00
- variantTP53 R337Pcivic_curation1.00
- variantTP53 R342Pcivic_curation1.00
Curated evidence
Evidence citing this paper (5)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 20978130
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| TP53 L330P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9806Cancer-associated TP53 mutations were assessed for effects on the stability and oligomeric structure of p53. TP53 L330P protein eluted as a single peak contemporaneously with the known monomer mutant … (full text at CIViC) PMID 20978130 · Kamada et al., 2011 · Open in CIViC | civic |
| TP53 L330R1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9807Cancer-associated TP53 mutations were assessed for effects on the stability and oligomeric structure of p53. TP53 L330R protein eluted as a single peak contemporaneously with the known monomer mutant … (full text at CIViC) PMID 20978130 · Kamada et al., 2011 · Open in CIViC | civic |
| TP53 L344P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9809Cancer-associated TP53 mutations were assessed for effects on the stability and oligomeric structure of p53. TP53 L344P protein eluted as a single peak contemporaneously with the known monomer mutant … (full text at CIViC) PMID 20978130 · Kamada et al., 2011 · Open in CIViC | civic |
| TP53 R337P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9808Cancer-associated TP53 mutations were assessed for effects on the stability and oligomeric structure of p53. TP53 R337P protein eluted as a single peak contemporaneously with the known monomer mutant … (full text at CIViC) PMID 20978130 · Kamada et al., 2011 · Open in CIViC | civic |
| TP53 R342P1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 3 | accepted | EID9805Cancer-associated TP53 mutations were assessed for effects on the stability and oligomeric structure of p53. TP53 R324P protein eluted as a single peak contemporaneously with the known monomer mutant … (full text at CIViC) PMID 20978130 · Kamada et al., 2011 · Open in CIViC | civic |