Publication
PIK3CA mutation associates with improved outcome in breast cancer.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMalignant Breast Neoplasmcivic_curation1.00
- genePIK3CAcivic_curation1.00
- variantPIK3CA H1047Rcivic_curation1.00
- variantPIK3CA Mutationcivic_curation1.00
- variantPIK3CA Rare Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (4)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 19671852
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PIK3CA H1047R1 | ||||||||
| (prognostic) | Malignant Breast Neoplasm | Prognostic | B | Supports Better Outcome | 2 | accepted | EID2097Prognostic significance of PIK3CA mutations was evaluated in a retrospective study of 590 patients with surgically resected invasive breast cancer. Patients whose tumors harbored PIK3CA H1047R (n=88, … (full text at CIViC) PMID 19671852 · Kalinsky et al., 2009 · Open in CIViC | civic |
| PIK3CA Mutation1 | ||||||||
| (prognostic) | Malignant Breast Neoplasm | Prognostic | B | Supports Better Outcome | 3 | accepted | EID2025Prognostic significance of PIK3CA mutations was evaluated in a retrospective study of 590 patients with surgically resected invasive breast cancer. Patients with tumors harboring PIK3CA mutations (n=1… (full text at CIViC) PMID 19671852 · Kalinsky et al., 2009 · Open in CIViC | civic |
| PIK3CA Rare Mutation2 | ||||||||
| (prognostic) | Malignant Breast Neoplasm | Prognostic | B | Supports Better Outcome | 2 | accepted | EID2042Prognostic significance of PIK3CA mutations was evaluated in a retrospective study of 590 patients with surgically resected invasive breast cancer. Tumors harboring rare PIK3CA mutations (N345K: 2.4%,… (full text at CIViC) PMID 19671852 · Kalinsky et al., 2009 · Open in CIViC | civic |
| 〃 | Malignant Breast Neoplasm | Prognostic | B | Supports Better Outcome | 2 | rejected | EID8915Prognostic significance of PIK3CA mutations was evaluated in a retrospective study of 590 patients with surgically resected invasive breast cancer. Tumors harboring rare PIK3CA mutations (N345K: 2.4%,… (full text at CIViC) PMID 19671852 · Kalinsky et al., 2009 · Open in CIViC | civic |