Publication
Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerDesmoid Fibromatosiscivic_curation1.00
- geneCTNNB1civic_curation1.00
- variantCTNNB1 S45Fcivic_curation1.00
- variantCTNNB1 S45Pcivic_curation1.00
- variantCTNNB1 T41Acivic_curation1.00
Curated evidence
Evidence citing this paper (6)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 18832571
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CTNNB1 S45F2 | ||||||||
| (diagnostic) | Desmoid FibromatosisALIAS | Diagnostic | B | Supports Positive | 4 | accepted | EID2974Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Beta-Catenin deregulation has been commonly identified in sporadic desmoids. CTNNB1 mutat… (full text at CIViC) PMID 18832571 · Lazar et al., 2008 · Open in CIViC | civic |
| (prognostic) | Desmoid FibromatosisALIAS | Prognostic | B | Supports Poor Outcome | 3 | accepted | EID2976Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Beta-Catenin deregulation has been commonly identified in sporadic desmoids. CTNNB1 mutat… (full text at CIViC) PMID 18832571 · Lazar et al., 2008 · Open in CIViC | civic |
| CTNNB1 S45P2 | ||||||||
| (diagnostic) | Desmoid FibromatosisALIAS | Diagnostic | B | Supports Positive | 3 | accepted | EID2975Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Beta-Catenin deregulation has been commonly identified in sporadic desmoids. CTNNB1 mutat… (full text at CIViC) PMID 18832571 · Lazar et al., 2008 · Open in CIViC | civic |
| (prognostic) | Desmoid FibromatosisALIAS | Prognostic | B | Supports Better Outcome | 1 | accepted | EID3043Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Beta-Catenin deregulation has been commonly identified in sporadic desmoids. CTNNB1 mutat… (full text at CIViC) PMID 18832571 · Lazar et al., 2008 · Open in CIViC | civic |
| CTNNB1 T41A2 | ||||||||
| (diagnostic) | Desmoid FibromatosisALIAS | Diagnostic | B | Supports Positive | 4 | accepted | EID2973Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Beta-Catenin deregulation has been commonly identified in sporadic desmoids. CTNNB1 mutat… (full text at CIViC) PMID 18832571 · Lazar et al., 2008 · Open in CIViC | civic |
| (prognostic) | Desmoid FibromatosisALIAS | Prognostic | B | Supports Better Outcome | 3 | accepted | EID3044In an analysis of 138 desmoid fibromatosis tumors, which is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence, 117 tumors (85%) had CTNNB1 mutations. Three discrete… (full text at CIViC) PMID 18832571 · Lazar et al., 2008 · Open in CIViC | civic |