CTNNB1 S45P

CI-VAR-00004071Explore in graph →NP_001895.1:p.Ser45ProNM_001904.3:c.133T>CClinVar 17589 CIViC 1287 rs121913407

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Desmoid Fibromatosis3
CTNNB1 S45P	(diagnostic)	Diagnostic	B	Supports Positive	3	accepted	EID2975 Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Beta-Catenin deregulation has been commonly identified in sporadic desmoids. CTNNB1 mutat… (full text at CIViC) PMID 18832571 · Lazar et al., 2008 · Open in CIViC	civic
CTNNB1 S45P	(prognostic)	Prognostic	B	Supports Better Outcome	1	accepted	EID3043 Desmoid fibromatosis is a rare, nonmetastatic neoplasm marked by local invasiveness and relentless recurrence. Beta-Catenin deregulation has been commonly identified in sporadic desmoids. CTNNB1 mutat… (full text at CIViC) PMID 18832571 · Lazar et al., 2008 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
17589	Pathogenic/Likely pathogenic	no assertion criteria provided	0	Hepatocellular carcinoma; Neoplasm; Desmoid tumor; Embryonal rhabdomyosarcoma	somatic	4	Jul 08, 1999	clinvar