Publication
FISH analysis of 107 prostate cancers shows that PTEN genomic deletion is associated with poor clinical outcome.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerProstate Adenocarcinomacivic_curation1.00
- genePTENcivic_curation1.00
- variantPTEN Deletioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 17700571
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PTEN Deletion2 | ||||||||
| (prognostic) | Malignant Prostate Neoplasm | Prognostic | B | Supports Poor Outcome | 4 | rejected | EID643PTEN Loss (by FISH) is associated with poorer prognosis in patients with prostate cancer. PMID 17700571 · Yoshimoto et al., 2007 · Open in CIViC | civic |
| 〃 | Prostate Adenocarcinoma | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID505In a study of 107 prostate adenocarcinomas, those with either hemi- or homozygous deletions of PTEN (as determined by interphase FISH) have shorter biochemical recurence-free survival than those witho… (full text at CIViC) PMID 17700571 · Yoshimoto et al., 2007 · Open in CIViC | civic |