PTEN Deletion

CI-VAR-00000630Explore in graph →CIViC 213

Curated evidence

Evidence by cancer (5 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–5 of 5 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Prostate Neoplasm3
PTEN Deletion	(prognostic)	Prognostic	B	Supports Poor Outcome	4	rejected	EID643 PTEN Loss (by FISH) is associated with poorer prognosis in patients with prostate cancer. PMID 17700571 · Yoshimoto et al., 2007 · Open in CIViC	civic
PTEN Deletion	(prognostic)	Prognostic	B	Supports Poor Outcome	4	accepted	EID1741 A meta-analysis of 26 published studies including 8097 prostate cancer patients showed that, compared to patients with normal PTEN, patients with PTEN deletion exhibited a greater aggressive Gleason s… (full text at CIViC) PMID 27470558 · Gao et al., 2016 · Open in CIViC	civic
PTEN Deletion	Everolimus

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Prostate Adenocarcinoma1
PTEN Deletion	(prognostic)	Prognostic	B	Supports Poor Outcome	4	accepted	EID505 In a study of 107 prostate adenocarcinomas, those with either hemi- or homozygous deletions of PTEN (as determined by interphase FISH) have shorter biochemical recurence-free survival than those witho… (full text at CIViC) PMID 17700571 · Yoshimoto et al., 2007 · Open in CIViC	civic

Uterine Corpus Leiomyosarcoma1
PTEN Deletion AND BRCA2 Deletion AND TP53 Deletion	Olaparib	Predictive	C	Supports Sensitivity Response	2	submitted	EID11319 In this case study, the patient, a 54-year-old African woman, presented with pelvic pain in May 2019 and was found to have a solid heterogeneous pelvic mass with areas of fluid and hemorrhagic density… (full text at CIViC) PMID 33970096 · Pan et al., 2021 · Open in CIViC	civic