Publication
Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation.
Authors not recorded
Hum Mol Genet2006PMID 16717057stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerCIC-Rearranged Sarcomacivic_curation1.00
- geneDUX4civic_curation1.00
- variantDUX4 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16717057
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| DUX4 Fusion1 | ||||||||
| (oncogenic) | CIC-Rearranged Sarcoma | Oncogenic | C | Supports Oncogenicity | 3 | accepted | EID10112Kawamura-Saito, et al. (2006) presented 2 soft tissue Ewing-like sarcoma cases (62 years of age female who deceased 10 months after biopsy; 31 years of age male who was without recurrence 30 months af… (full text at CIViC) PMID 16717057 · Kawamura-Saito et al., 2006 · Open in CIViC | civic |