Publication
CDKN2B methylation is an independent poor prognostic factor in newly diagnosed acute promyelocytic leukemia.
Authors not recorded
Leukemia2006PMID 16307009stubpubmedProvenance
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerAcute Promyelocytic Leukemiacivic_curation1.00
- geneCDKN2Bcivic_curation1.00
- variantCDKN2B METHYLATIONcivic_curation1.00
Curated evidence
Evidence citing this paper (1)
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 16307009
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| CDKN2B METHYLATION1 | ||||||||
| (prognostic) | Acute Promyelocytic Leukemia | Prognostic | B | Supports Poor Outcome | 4 | accepted | EID1848This study analyses 45 new acute promyelocytic leukemia patients (22 male and 23 female). CDKN2B was found to be a negative prognostic biomarker for disease free survival (DFS). The 5-year DFS was 9.6… (full text at CIViC) PMID 16307009 · Chim et al., 2006 · Open in CIViC | civic |