Publication
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerMalignant Neoplasmcivic_curation1.00
- genePTENcivic_curation1.00
- variantPTEN R173Ccivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 10866302
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PTEN R173C1 | ||||||||
| (predisposing) | Malignant NeoplasmALIAS | Predisposing | D | Supports Uncertain Significance | 3 | accepted | EID1930Han et al functionally tested the R173C mutation in PTEN using an expression vector construct, assessing phosphatase activity of the mutant construct with two phosphoinositide substrates ("with[ PtdIn… (full text at CIViC) PMID 10866302 · Han et al., 2000 · Open in CIViC | civic |
| PTEN R130Q1 | ||||||||
| (functional) | —UNRESOLVED | Functional | D | Supports Loss Of Function | 2 | submitted | EID7693Missense mutations in PTEN were characterized for phosphatase activity and the ability to bind a phospholipid membrane. Phosphatase assays revealed that PTEN R130Q retains no phosphatase activity in v… (full text at CIViC) PMID 10866302 · Han et al., 2000 · Open in CIViC | civic |