TP53 Mutation

other

Identifier: CI-VAR-00002658
Entity page: /variant/tp53-mutation ↗
Edges: 38

Neighbours: 14 cancers11 drugs
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
TP53 Mutation predicts response to …PREDICTS_RESPONSE_TO12 of 12
→ predicts response to	Alemtuzumabmonoclonal_antibody	sensitivity	B	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ predicts response to	VEGF/VEGFR Inhibitors	sensitivity	B

TP53 Mutation prognostic in …PROGNOSTIC_IN12 of 12
→ prognostic in	Chronic Lymphocytic Leukemiahematologic_malignancy	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ prognostic in	Chronic Lymphocytic Leukemiahematologic_malignancy 5 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	5	Curated	civic	graph →
→ prognostic in	B Lymphoblastic Leukemia/Lymphomahematologic_malignancy 2 source records aggregated	supports	B	B Lymphoblastic Leukemia/Lymphoma	2	Curated	civic	graph →
→ prognostic in	Adrenal Cortical Carcinomasubtype	supports	B	Adrenal Cortical Carcinoma	1	Curated	civic	graph →
→ prognostic in	Malignant Breast Neoplasmcancer_family	supports	B	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ prognostic in	Acute Myeloid Leukemiahematologic_malignancy	supports	B	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ prognostic in	Head and Neck Squamous Cell Carcinomasubtype	supports	B	Head and Neck Squamous Cell Carcinoma	1	Curated	civic	graph →
→ prognostic in	Myeloid Neoplasmcancer_family	supports	B	Myeloid Neoplasm	1	Curated	civic	graph →
→ prognostic in	Myelodysplastic Syndromehematologic_malignancy	supports	B	Myelodysplastic Syndrome	1	Curated	civic	graph →
→ prognostic in	Esophageal Squamous Cell Carcinomasubtype	supports	B	Esophageal Squamous Cell Carcinoma	1	Curated	civic	graph →
→ prognostic in	Medulloblastoma, SHH-Activatedsubtype	supports	B	Medulloblastoma, SHH-Activated	1	Curated	civic	graph →
→ prognostic in	Lung Non-Small Cell Carcinomasubtype	supports	B	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →

TP53 Mutation prognostic in …PROGNOSTIC_IN12 of 12

→ prognostic in

Chronic Lymphocytic Leukemiahematologic_malignancy

supports

Chronic Lymphocytic Leukemia

Curated

TP53 Mutation has curated evidence in …HAS_EVIDENCE_INderived14 of 14
→ has curated evidence in	Chronic Lymphocytic Leukemiahematologic_malignancy 7 accepted items · levels A, B · 1 sensitivity / 0 resistance · 7 supports / 0 does not support	sensitivity	A	Chronic Lymphocytic Leukemia	7	Curated	civic	graph →
→ has curated evidence in	Head and Neck Squamous Cell Carcinomasubtype 3 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 2 does not support	does not support	B	Head and Neck Squamous Cell Carcinoma	3	Curated	civic	graph →
→ has curated evidence in	Malignant Breast Neoplasmcancer_family 3 accepted items · levels B, C, D · 1 sensitivity / 1 resistance · 3 supports / 0 does not support	mixed	B	Malignant Breast Neoplasm	3	Curated	civic	graph →
→ has curated evidence in	B Lymphoblastic Leukemia/Lymphomahematologic_malignancy 2 accepted items · levels B · 0 sensitivity / 0 resistance · 2 supports / 0 does not support	supports	B	B Lymphoblastic Leukemia/Lymphoma	2	Curated	civic	graph →
→ has curated evidence in	Lung Non-Small Cell Carcinomasubtype 2 accepted items · levels B, D · 1 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	B	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has curated evidence in	Myelodysplastic Syndromehematologic_malignancy 2 accepted items · levels B · 1 sensitivity / 0 resistance · 2 supports / 0 does not support	sensitivity	B	Myelodysplastic Syndrome	2	Curated	civic	graph →
→ has curated evidence in	Acute Myeloid Leukemiahematologic_malignancy 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ has curated evidence in	Adrenal Cortical Carcinomasubtype 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Adrenal Cortical Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Esophageal Squamous Cell Carcinomasubtype 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Esophageal Squamous Cell Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Gastric Adenocarcinoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Gastric Adenocarcinoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Medulloblastoma, SHH-Activatedsubtype 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Medulloblastoma, SHH-Activated	1	Curated	civic	graph →
→ has curated evidence in	Myeloid Neoplasmcancer_family 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Myeloid Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Gastric Carcinoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Gastric Carcinoma	1	Curated	civic	graph →

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