PTEN Loss

deletion cna

Identifier: CI-VAR-00002471
Entity page: /variant/pten-loss ↗
Edges: 39

Neighbours: 14 cancers17 drugs
Drawn: 31 of 31 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PTEN Loss predicts response to …PREDICTS_RESPONSE_TO18 of 25show all (up to 200)
→ predicts response to	Trastuzumabmonoclonal_antibody 5 source records aggregated	resistance	B	Gastric Adenocarcinoma,HER2-Positive Breast Carcinoma,Malignant Breast Neoplasm	5	Curated	civic

PTEN Loss has curated evidence in …HAS_EVIDENCE_INderived14 of 14
→ has curated evidence in	HER2-Positive Breast Carcinoma 10 accepted items · levels B, D · 4 sensitivity / 6 resistance · 8 supports / 2 does not support	mixed	B	HER2-Positive Breast Carcinoma	10	Curated	civic	graph →
→ has curated evidence in	Malignant Breast Neoplasm 6 accepted items · levels B, D · 3 sensitivity / 3 resistance · 4 supports / 2 does not support	mixed	B	Malignant Breast Neoplasm	6	Curated	civic	graph →
→ has curated evidence in	Malignant Neoplasm 3 accepted items · levels B, C, D · 3 sensitivity / 0 resistance · 2 supports / 1 does not support	sensitivity	B	Malignant Neoplasm	3	Curated	civic	graph →
→ has curated evidence in	Malignant Colorectal Neoplasm 2 accepted items · levels B · 0 sensitivity / 2 resistance · 2 supports / 0 does not support	resistance	B	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has curated evidence in	Malignant Endometrial Neoplasm 2 accepted items · levels B, D · 1 sensitivity / 1 resistance · 1 supports / 1 does not support	mixed	B	Malignant Endometrial Neoplasm	2	Curated	civic	graph →
→ has curated evidence in	Bladder Carcinoma 1 accepted items · levels B · 0 sensitivity / 1 resistance · 1 supports / 0 does not support	resistance	B	Bladder Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Gastric Adenocarcinoma 1 accepted items · levels B · 0 sensitivity / 1 resistance · 1 supports / 0 does not support	resistance	B	Gastric Adenocarcinoma	1	Curated	civic	graph →
→ has curated evidence in	Gastric Carcinoma 1 accepted items · levels B · 0 sensitivity / 1 resistance · 1 supports / 0 does not support	resistance	B	Gastric Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Solid Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 0 supports / 1 does not support	sensitivity	B	Solid Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Pancreatic Carcinoma 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Pancreatic Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Gastric Neoplasm 2 accepted items · levels D · 1 sensitivity / 1 resistance · 2 supports / 0 does not support	mixed	D	Malignant Gastric Neoplasm	2	Curated	civic	graph →
→ has curated evidence in	Malignant Ovarian Neoplasm 1 accepted items · levels D · 0 sensitivity / 1 resistance · 1 supports / 0 does not support	resistance	D	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Prostate Neoplasm 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Malignant Prostate Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Melanoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Melanoma	1	Curated	civic	graph →

PTEN Loss has curated evidence in …HAS_EVIDENCE_INderived14 of 14

→ has curated evidence in

HER2-Positive Breast Carcinoma

10 accepted items · levels B, D · 4 sensitivity / 6 resistance · 8 supports / 2 does not support

mixed

HER2-Positive Breast Carcinoma

Curated

civic

graph →

→ has curated evidence in

Malignant Breast Neoplasm

6 accepted items · levels B, D · 3 sensitivity / 3 resistance · 4 supports / 2 does not support