PIK3CA H1047R

SNV

Identifier: CI-VAR-00001873
Entity page: /variant/pik3ca-h1047r ↗
Edges: 35

Neighbours: 8 cancers16 drugs
Drawn: 24 of 24 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PIK3CA H1047R predicts response to …PREDICTS_RESPONSE_TO18 of 25show all (up to 200)
→ predicts response to	Fulvestrantsmall_molecule 2 source records aggregated	sensitivity	A	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ predicts response to	Inavolisibsmall_molecule

PIK3CA H1047R prognostic in …PROGNOSTIC_IN2 of 2
→ prognostic in	Malignant Breast Neoplasmcancer_family 2 source records aggregated	supports	B	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ prognostic in	Breast Tubular Carcinomasubtype	supports	B	Breast Tubular Carcinoma	1	Curated	civic	graph →

PIK3CA H1047R prognostic in …PROGNOSTIC_IN2 of 2

→ prognostic in

Malignant Breast Neoplasmcancer_family

2 source records aggregated

supports

Malignant Breast Neoplasm

Curated

civic

graph →

→ prognostic in

Breast Tubular Carcinomasubtype

supports

Breast Tubular Carcinoma

Curated

civic

graph →

PIK3CA H1047R has curated evidence in …HAS_EVIDENCE_INderived8 of 8
→ has curated evidence in	Malignant Breast Neoplasmcancer_family 7 accepted items · levels A, B, D · 4 sensitivity / 1 resistance · 6 supports / 1 does not support	mixed	A	Malignant Breast Neoplasm	7	Curated	civic	graph →
→ has curated evidence in	Malignant Colorectal Neoplasm 5 accepted items · levels B, C, D · 1 sensitivity / 4 resistance · 4 supports / 1 does not support	mixed	B	Malignant Colorectal Neoplasm	5	Curated	civic	graph →
→ has curated evidence in	Breast Tubular Carcinomasubtype 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Breast Tubular Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	HER2-Positive Breast Carcinoma 10 accepted items · levels C, D · 4 sensitivity / 6 resistance · 8 supports / 2 does not support	mixed	C	HER2-Positive Breast Carcinoma	10	Curated	civic	graph →
→ has curated evidence in	Malignant Head and Neck Neoplasm 4 accepted items · levels D · 4 sensitivity / 0 resistance · 4 supports / 0 does not support	sensitivity	D	Malignant Head and Neck Neoplasm	4	Curated	civic	graph →
→ has curated evidence in	Head and Neck Squamous Cell Carcinoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Head and Neck Squamous Cell Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Lung Adenocarcinoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Thyroid Gland Neoplasm 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Malignant Thyroid Gland Neoplasm	1	Curated	civic	graph →

PIK3CA H1047R has curated evidence in …HAS_EVIDENCE_INderived8 of 8

→ has curated evidence in

Malignant Breast Neoplasmcancer_family

7 accepted items · levels A, B, D · 4 sensitivity / 1 resistance · 6 supports / 1 does not support

mixed

Malignant Breast Neoplasm

Curated

civic

graph →

→ has curated evidence in

Malignant Colorectal Neoplasm

5 accepted items · levels B, C, D · 1 sensitivity / 4 resistance · 4 supports / 1 does not support