PIK3CA E545K

SNV

Identifier: CI-VAR-00000778
Entity page: /variant/pik3ca-e545k ↗
Edges: 34

Neighbours: 11 cancers19 drugs
Drawn: 30 of 30 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PIK3CA E545K predicts response to …PREDICTS_RESPONSE_TO19 of 22show all (up to 200)
→ predicts response to	Fulvestrantsmall_molecule 2 source records aggregated	sensitivity	A	Malignant Breast Neoplasm	2	Curated	civic	graph →
→ predicts response to	Inavolisibsmall_molecule

PIK3CA E545K prognostic in …PROGNOSTIC_IN1 of 1
→ prognostic in	Rectal Carcinomasubtype	supports	B	Rectal Carcinoma	1	Curated	civic	graph →

PIK3CA E545K prognostic in …PROGNOSTIC_IN1 of 1

→ prognostic in

Rectal Carcinomasubtype

supports

Rectal Carcinoma

Curated

civic

graph →

PIK3CA E545K has curated evidence in …HAS_EVIDENCE_INderived11 of 11
→ has curated evidence in	Malignant Breast Neoplasm 7 accepted items · levels A, B, D · 5 sensitivity / 2 resistance · 6 supports / 1 does not support	mixed	A	Malignant Breast Neoplasm	7	Curated	civic	graph →
→ has curated evidence in	Rectal Carcinomasubtype 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Rectal Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Colorectal Neoplasm 3 accepted items · levels C · 0 sensitivity / 3 resistance · 1 supports / 2 does not support	resistance	C	Malignant Colorectal Neoplasm	3	Curated	civic	graph →
→ has curated evidence in	Lung Adenocarcinoma 2 accepted items · levels C, D · 0 sensitivity / 2 resistance · 2 supports / 0 does not support	resistance	C	Lung Adenocarcinoma	2	Curated	civic	graph →
→ has curated evidence in	Malignant Neoplasm 1 accepted items · levels C · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	C	Malignant Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Urothelial Carcinoma 1 accepted items · levels C · 0 sensitivity / 1 resistance · 1 supports / 0 does not support	resistance	C	Urothelial Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	HER2-Positive Breast Carcinoma 9 accepted items · levels D · 2 sensitivity / 7 resistance · 7 supports / 2 does not support	mixed	D	HER2-Positive Breast Carcinoma	9	Curated	civic	graph →
→ has curated evidence in	Malignant Cervical Neoplasm 2 accepted items · levels D · 0 sensitivity / 2 resistance · 2 supports / 0 does not support	resistance	D	Malignant Cervical Neoplasm	2	Curated	civic	graph →
→ has curated evidence in	Cervical Carcinoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Cervical Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Lung Non-Small Cell Carcinoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Melanoma 1 accepted items · levels D · 0 sensitivity / 1 resistance · 1 supports / 0 does not support	resistance	D	Melanoma	1	Curated	civic	graph →

PIK3CA E545K has curated evidence in …HAS_EVIDENCE_INderived11 of 11

→ has curated evidence in

Malignant Breast Neoplasm

7 accepted items · levels A, B, D · 5 sensitivity / 2 resistance · 6 supports / 1 does not support