KRAS Mutation

other

Identifier: CI-VAR-00002669
Entity page: /variant/kras-mutation ↗
Edges: 60

Neighbours: 11 cancers39 drugs
Drawn: 50 of 50 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
KRAS Mutation predicts response to …PREDICTS_RESPONSE_TO50 of 46show fewer
→ predicts response to	Panitumumabmonoclonal_antibody	resistance	A	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ predicts response to	Cetuximabmonoclonal_antibody	resistance

KRAS Mutation prognostic in …PROGNOSTIC_IN3 of 3
→ prognostic in	Lung Non-Small Cell Carcinomasubtype	supports	B	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ prognostic in	Pseudomyxoma Peritoneisubtype	supports	B	Pseudomyxoma Peritonei	1	Curated	civic	graph →
→ prognostic in	Lung Adenocarcinomasubtype	supports	B	Lung Adenocarcinoma	1	Curated	civic	graph →

KRAS Mutation has curated evidence in …HAS_EVIDENCE_INderived11 of 11
→ has curated evidence in	Lung Non-Small Cell Carcinomasubtype 19 accepted items · levels A, B, D, E · 13 sensitivity / 5 resistance · 14 supports / 5 does not support	mixed	A	Lung Non-Small Cell Carcinoma	19	Curated	civic	graph →
→ has curated evidence in	Malignant Colorectal Neoplasm 16 accepted items · levels A, B, C, D · 10 sensitivity / 6 resistance · 13 supports / 3 does not support	mixed	A	Malignant Colorectal Neoplasm	16	Curated	civic	graph →
→ has curated evidence in	Malignant Neoplasm 5 accepted items · levels B, D · 5 sensitivity / 0 resistance · 3 supports / 2 does not support	sensitivity	B	Malignant Neoplasm	5	Curated	civic	graph →
→ has curated evidence in	Lung Adenocarcinomasubtype 2 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 1 does not support	sensitivity	B	Lung Adenocarcinoma	2	Curated	civic	graph →
→ has curated evidence in	Hepatocellular Carcinoma 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Hepatocellular Carcinoma	1	Curated	civic	graph →
→ has curated evidence in	Malignant Endometrial Neoplasm 1 accepted items · levels B · 1 sensitivity / 0 resistance · 0 supports / 1 does not support	sensitivity	B	Malignant Endometrial Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Malignant Ovarian Serous Tumor 1 accepted items · levels B · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	B	Malignant Ovarian Serous Tumor	1	Curated	civic	graph →
→ has curated evidence in	Melanoma 1 accepted items · levels B · 0 sensitivity / 1 resistance · 1 supports / 0 does not support	resistance	B	Melanoma	1	Curated	civic	graph →
→ has curated evidence in	Pseudomyxoma Peritoneisubtype 1 accepted items · levels B · 0 sensitivity / 0 resistance · 1 supports / 0 does not support	supports	B	Pseudomyxoma Peritonei	1	Curated	civic	graph →
→ has curated evidence in	Malignant Ovarian Neoplasm 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Malignant Ovarian Neoplasm	1	Curated	civic	graph →
→ has curated evidence in	Pancreatic Adenocarcinoma 1 accepted items · levels D · 1 sensitivity / 0 resistance · 1 supports / 0 does not support	sensitivity	D	Pancreatic Adenocarcinoma	1	Curated	civic	graph →

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