TYMS

thymidylate synthetase

Identifier: CI-GENE-00037654
Entity page: /gene/TYMS ↗
Edges: 25

Neighbours: 7 cancers13 variants5 drugs
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
TYMS associated with …ASSOCIATED_WITH6 of 6
→ associated with	Lung Non-Small Cell Carcinomasubtype 3 source records aggregated	supports	B	Lung Non-Small Cell Carcinoma	3	Curated	civic	graph →
→ associated with	Gastric Adenocarcinomasubtype	supports

TYMS targets …TARGETS5 of 5
← targets	Tegafursmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Raltitrexedsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pemetrexedsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Fluorouracilsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Capecitabinesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

TYMS targets …TARGETS5 of 5

← targets

Tegafursmall_molecule

—

INHIBITOR

—

Curated

TYMS has variant …HAS_VARIANTderived13 of 13
→ has variant	Overexpressionexpression 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Gastric Adenocarcinoma	3	Curated	civic	graph →
→ has variant	Underexpressionexpression 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Malignant Prostate Neoplasm	2	Curated	civic	graph →
→ has variant	3TRP/3TRP genotype 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	Amplificationamplification 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	RS34743033 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Decreased RNA expressionexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001071.4(TYMS):c.259G>A (p.Glu87Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001071.4(TYMS):c.343C>T (p.Arg115Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001071.4(TYMS):c.480A>T (p.Gln160His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001071.4(TYMS):c.486_487del (p.Arg163fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001071.4(TYMS):c.534_535insTG (p.Met179Ter)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001071.4(TYMS):c.556+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001071.4(TYMS):c.811C>T (p.Arg271Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

Radial view

Every edge, grouped by relationship

Paths