TOP2B

DNA topoisomerase II beta

Identifier: CI-GENE-00035890
Entity page: /gene/TOP2B ↗
Edges: 15

Neighbours: 12 variants3 drugs
Drawn: 15 of 15 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
TOP2B targets …TARGETS3 of 3
← targets	Teniposidesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Etoposidesmall_molecule	—	INHIBITOR	—	1	Curated	chembl

TOP2B has variant …HAS_VARIANTderived12 of 12
→ has variant	NM_001330700.2(TOP2B):c.1027-7deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.1473G>T (p.Val491=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.2862+1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.3365A>G (p.Asp1122Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.396-28_396-5deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.396-29_396-5deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.396-3C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.396-4A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.396-5T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.4022A>G (p.Lys1341Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.4489+5G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_001330700.2(TOP2B):c.4738G>C (p.Asp1580His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →

TOP2B has variant …HAS_VARIANTderived12 of 12

→ has variant

NM_001330700.2(TOP2B):c.1027-7deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_001330700.2(TOP2B):c.1473G>T (p.Val491=)SNV

no accepted CIViC evidence item (variant record only)