Gene
TOP2B
DNA topoisomerase II beta
Explore in graph →CI-GENE-00035890HGNC:11990 ENSG00000077097 NCBI 7155 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (3)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 33585982
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Cutaneous Neurofibroma Data Resource (CTF, Scientific Data 2021) nfib_ctf_biobank_2025 | Neurofibroma | Ssm | 6 | 38 | 15.8% | 143 | cbioportal |
| Anaplastic Thyroid Cancers (GATCI, Cell Reports 2024) thyroid_gatci_2024 | unmapped | Ssm | 7 | 190 | 3.7% | 152 | cbioportal |
| Glioblastoma (CPTAC, Cell 2021) gbm_cptac_2021 | Diffuse Glioma | Ssm | 3 | 99 | 3% | 193 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.