Knowledge graph · Gene
TOP2A
DNA topoisomerase II alpha
- Identifier
- CI-GENE-00035889
- Entity page
- /gene/TOP2A ↗
- Edges
- 16
- Neighbours
- 1 cancers6 variants9 drugs
- Drawn
- 16 of 16 neighbours (cap 60); table lists every fetched edge
Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.
Most connectedLung Non-Small Cell Carcinoma 3,149Malignant Colorectal Neoplasm 1,866ABL1 298EGFR 276Imatinib 450Dasatinib 321
Neighbourhood
Radial view
Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.
Edges
Every edge, grouped by relationship
Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.
| Relationship | Neighbour | Direction | Evidence level | Cancer context | Support | Claim | Source | Expand |
|---|---|---|---|---|---|---|---|---|
| TOP2A associated with …ASSOCIATED_WITH1 of 1 | ||||||||
| → associated with | Malignant Breast Neoplasmcancer_family | supports | B | Malignant Breast Neoplasm | 1 | Curated | civic | graph → |
| TOP2A targets …TARGETS9 of 9 | ||||||||
| ← targets | ||||||||