STAG2

STAG2 cohesin complex component

Identifier: CI-GENE-00033984
Entity page: /gene/STAG2 ↗
Edges: 40

Neighbours: 9 cancers15 variants
Drawn: 24 of 24 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
STAG2 associated with …ASSOCIATED_WITH3 of 3
→ associated with	Bladder Carcinomasubtype	supports	B	Bladder Carcinoma	1	Curated	civic	graph →
→ associated with	Bone Ewing Sarcomasubtype	supports	B

STAG2 has variant …HAS_VARIANTderived15 of 31show all (up to 200)
→ has variant	MUTATIONother 2 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia,Bone Ewing Sarcoma	2	Curated	civic	graph →
→ has variant	Underexpressionexpression 2 accepted CIViC evidence items	—	—	Melanoma,Bladder Carcinoma	2	Curated	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	LOSS-OF-FUNCTION no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042749.2(STAG2):c.1535-3T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.1266G>T (p.Arg422=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.1407A>G (p.Leu469=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.1416+95A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.1449C>T (p.Ser483=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.1541_1542del (p.Thr514fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.161G>T (p.Gly54Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.1651A>G (p.Lys551Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.1707G>A (p.Val569=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.1751del (p.Lys584fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001042750.2(STAG2):c.1840C>T (p.Arg614Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

STAG2 has variant …HAS_VARIANTderived15 of 31show all (up to 200)

→ has variant

MUTATIONother

2 accepted CIViC evidence items

—

Acute Myeloid Leukemia,Bone Ewing Sarcoma

Curated

STAG2 altered in cohorts of …ALTERED_INderived6 of 6
→ altered in cohorts of	Renal Pelvis and Ureter Urothelial Carcinoma 24 / 119 cases (20 %) · ssm · utuc_msk_2019	—	—	Renal Pelvis and Ureter Urothelial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 55 / 474 cases (12 %) · ssm · blca_msk_tcga_2020 · largest of 6 cohorts	—	—	Bladder Urothelial Carcinoma	6	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndrome 312 / 3,323 cases (9.4 %) · ssm · mds_iwg_2022	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →
→ altered in cohorts of	Acute Myeloid Leukemia 60 / 903 cases (6.6 %) · ssm · aml_ohsu_2022 · largest of 2 cohorts	—	—	Acute Myeloid Leukemia	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 40 / 696 cases (5.7 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 30 / 527 cases (5.7 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

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