SMO

smoothened, frizzled class receptor

Identifier: CI-GENE-00031524
Entity page: /gene/SMO ↗
Edges: 37

Neighbours: 4 cancers15 variants4 drugs
Drawn: 23 of 23 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
SMO associated with …ASSOCIATED_WITH5 of 5
→ associated with	Basal Cell Carcinomahistology 2 source records aggregated	supports	B	Basal Cell Carcinoma	2	Curated	civic	graph →
→ associated with	Medulloblastomasubtype	supports	C

SMO targets …TARGETS4 of 4
← targets	Vismodegibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Sonidegibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Patidegibsmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Glasdegibsmall_molecule	—	ANTAGONIST	—	1	Curated	chembl	graph →

SMO has variant …HAS_VARIANTderived15 of 26show all (up to 200)
→ has variant	Mutationother 4 accepted CIViC evidence items	—	—	Malignant Neoplasm,Basal Cell Carcinoma	4	Curated	civic	graph →
→ has variant	D473HSNV 3 accepted CIViC evidence items	—	—	Basal Cell Carcinoma,Medulloblastoma	3	Curated	civic	graph →
→ has variant	L412FSNV 2 accepted CIViC evidence items	—	—	Basal Cell Carcinoma	2	Curated	civic	graph →
→ has variant	A459VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Amplificationamplification no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C469YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D473GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D473YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G497WSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	I408VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005631.5(SMO):c.1248C>G (p.Gly416=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005631.5(SMO):c.1570G>C (p.Ala524Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005631.5(SMO):c.1685G>A (p.Arg562Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005631.5(SMO):c.382G>A (p.Ala128Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_005631.5(SMO):c.621C>T (p.Tyr207=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

SMO altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Skin Basal Cell Carcinoma 66 / 293 cases (23 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 22 / 181 cases (12 %) · ssm · ucec_ccr_msk_2022	—	—	Endometrial Carcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths