SF3B1

splicing factor 3b subunit 1

Identifier: CI-GENE-00030440
Entity page: /gene/SF3B1 ↗
Edges: 20

Neighbours: 10 cancers8 variants
Drawn: 18 of 18 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
SF3B1 associated with …ASSOCIATED_WITH5 of 5
→ associated with	Chronic Lymphocytic Leukemiahematologic_malignancy	supports	A	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ associated with	Chronic Lymphocytic Leukemiahematologic_malignancy 3 source records aggregated	supports

SF3B1 has variant …HAS_VARIANTderived8 of 8
→ has variant	Mutationother 5 accepted CIViC evidence items	—	—	Myelodysplastic Syndrome,Chronic Lymphocytic Leukemia	5	Curated	civic	graph →
→ has variant	K700ESNV 2 accepted CIViC evidence items	—	—	Leukemia,Malignant Breast Neoplasm	2	Curated	civic	graph →
→ has variant	K666NSNV 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	K700ESNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_012433.4(SF3B1):c.1873C>T (p.Arg625Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_012433.4(SF3B1):c.1998G>C (p.Lys666Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_012433.4(SF3B1):c.2078-8T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_012433.4(SF3B1):c.2225G>C (p.Gly742Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

SF3B1 has variant …HAS_VARIANTderived8 of 8

→ has variant

Mutationother

5 accepted CIViC evidence items

—

Myelodysplastic Syndrome,Chronic Lymphocytic Leukemia

Curated

SF3B1 altered in cohorts of …ALTERED_INderived7 of 7
→ altered in cohorts of	Small Lymphocytic Lymphoma 174 / 1,075 cases (16 %) · ssm · cll_broad_2022 · largest of 4 cohorts	—	—	Small Lymphocytic Lymphoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndromehematologic_malignancy 378 / 4,231 cases (8.9 %) · ssm · mds_mskcc_2020 · largest of 2 cohorts	—	—	Myelodysplastic Syndrome	2	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 28 / 474 cases (5.9 %) · ssm · blca_msk_tcga_2020 · largest of 2 cohorts	—	—	Bladder Urothelial Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 40 / 696 cases (5.7 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 30 / 527 cases (5.7 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Acute Myeloid Leukemia 49 / 903 cases (5.4 %) · ssm · aml_ohsu_2022 · largest of 2 cohorts	—	—	Acute Myeloid Leukemia	2	Observed	cbioportal	graph →
→ altered in cohorts of	Cholangiocarcinoma 21 / 417 cases (5.0 %) · ssm · chol_icgc_2017	—	—	Cholangiocarcinoma	1	Observed	cbioportal	graph →

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