PTPRD

protein tyrosine phosphatase receptor type D

Identifier: CI-GENE-00022530
Entity page: /gene/PTPRD ↗
Edges: 25

Neighbours: 14 cancers11 variants
Drawn: 25 of 25 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PTPRD associated with …ASSOCIATED_WITH3 of 3
→ associated with	Ewing Sarcomasubtype	supports	C	Ewing Sarcoma	1	Curated	civic	graph →
→ associated with	Bone Ewing Sarcomasubtype	supports	C

PTPRD has variant …HAS_VARIANTderived11 of 11
→ has variant	Mutationother 1 accepted CIViC evidence items	—	—	Head and Neck Carcinoma	1	Curated	civic	graph →
→ has variant	R995CSNV 1 accepted CIViC evidence items	—	—	Ewing Sarcoma	1	Curated	civic	graph →
→ has variant	V253ISNV 1 accepted CIViC evidence items	—	—	Bone Ewing Sarcoma	1	Curated	civic	graph →
→ has variant	NM_002839.4(PTPRD):c.3030G>C (p.Gln1010His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002839.4(PTPRD):c.353-2A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002839.4(PTPRD):c.4789C>T (p.Gln1597Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002839.4(PTPRD):c.556A>T (p.Thr186Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002839.4(PTPRD):c.5692C>T (p.Arg1898Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002839.4(PTPRD):c.750C>T (p.Gly250=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	T781ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	W775*SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

PTPRD altered in cohorts of …ALTERED_INderived11 of 11
→ altered in cohorts of	Skin Basal Cell Carcinoma 61 / 126 cases (48 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 199 / 696 cases (29 %) · ssm · mel_mskimpact_2020 · largest of 9 cohorts	—	—	Cutaneous Melanoma	9	Observed	cbioportal	graph →
→ altered in cohorts of	Melanoma 23 / 144 cases (16 %) · ssm · mel_dfci_2019 · largest of 2 cohorts	—	—	Melanoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Esophageal Adenocarcinoma 22 / 151 cases (15 %) · ssm · esca_broad	—	—	Esophageal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 141 / 1,144 cases (12 %) · ssm · nsclc_tcga_broad_2016 · largest of 4 cohorts	—	—	Lung Non-Small Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 270 / 2,653 cases (10 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 10 cohorts	—	—	Lung Adenocarcinoma	10	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 30 / 295 cases (10 %) · ssm · stad_tcga_pub	—	—	Gastric Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 45 / 518 cases (8.7 %) · ssm · stes_tcga_pub · largest of 2 cohorts	—	—	Gastroesophageal Junction Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 42 / 527 cases (8.0 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 36 / 474 cases (7.6 %) · ssm · blca_msk_tcga_2020 · largest of 4 cohorts	—	—	Bladder Urothelial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Head and Neck Squamous Cell Carcinoma 27 / 515 cases (5.2 %) · ssm · hnsc_tcga_pan_can_atlas_2018 · largest of 2 cohorts	—	—	Head and Neck Squamous Cell Carcinoma	2	Observed	cbioportal	graph →

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