PRKCE

protein kinase C epsilon

Identifier: CI-GENE-00020997
Entity page: /gene/PRKCE ↗
Edges: 3

Neighbours: 1 variants2 drugs
Drawn: 3 of 3 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PRKCE targets …TARGETS2 of 2
← targets	Sotrastaurin Acetatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Midostaurinsmall_molecule	—	INHIBITOR	—	1	Curated	chembl

PRKCE has variant …HAS_VARIANTderived1 of 1
→ has variant	NM_005400.3(PRKCE):c.405G>A (p.Ser135=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

PRKCE has variant …HAS_VARIANTderived1 of 1

→ has variant

NM_005400.3(PRKCE):c.405G>A (p.Ser135=)SNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

Radial view

Every edge, grouped by relationship

Paths