PREX2

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

Identifier: CI-GENE-00020945
Entity page: /gene/PREX2 ↗
Edges: 22

Neighbours: 12 cancers9 variants
Drawn: 21 of 21 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
PREX2 associated with …ASSOCIATED_WITH1 of 1
→ associated with	Melanomacancer_family	supports	C	Melanoma	1	Curated	civic	graph →
PREX2 has variant …HAS_VARIANTderived9 of 9
→ has variant

PREX2 altered in cohorts of …ALTERED_INderived12 of 12
→ altered in cohorts of	Skin Basal Cell Carcinoma 110 / 293 cases (38 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 98 / 469 cases (21 %) · ssm · skcm_tcga_gdc · largest of 7 cohorts	—	—	Cutaneous Melanoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Melanomacancer_family 21 / 122 cases (17 %) · ssm · mel_iatlas_liu_2019	—	—	Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Colon Adenocarcinoma 33 / 281 cases (12 %) · ssm · coad_silu_2022	—	—	Colon Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Gastroesophageal Junction Adenocarcinoma 58 / 518 cases (11 %) · ssm · stes_tcga_pub · largest of 2 cohorts	—	—	Gastroesophageal Junction Adenocarcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Gastric Adenocarcinoma 50 / 478 cases (10 %) · ssm · stad_tcga · largest of 4 cohorts	—	—	Gastric Adenocarcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 23 / 236 cases (9.7 %) · ssm · bm_nsclc_mskcc_2023	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Squamous Cell Carcinoma 43 / 484 cases (8.9 %) · ssm · lusc_tcga_pan_can_atlas_2018 · largest of 4 cohorts	—	—	Lung Squamous Cell Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 28 / 407 cases (6.9 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 404 / 6,120 cases (6.6 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 25 / 408 cases (6.1 %) · ssm · blca_tcga_gdc	—	—	Bladder Urothelial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Hepatocellular Carcinoma 28 / 494 cases (5.7 %) · ssm · hcc_clca_2024	—	—	Hepatocellular Carcinoma	1	Observed	cbioportal	graph →

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