NPM1

nucleophosmin 1

Identifier: CI-GENE-00017093
Entity page: /gene/NPM1 ↗
Edges: 39

Neighbours: 3 cancers30 variants2 drugs
Drawn: 35 of 35 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
NPM1 associated with …ASSOCIATED_WITH5 of 5
→ associated with	Acute Myeloid Leukemiahematologic_malignancy	supports	A	Acute Myeloid Leukemia	1	Curated	civic	graph →
→ associated with	Acute Myeloid Leukemiahematologic_malignancy 23 source records aggregated

NPM1 targets …TARGETS2 of 2
← targets	Crizotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ceritinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

NPM1 targets …TARGETS2 of 2

← targets

Crizotinibsmall_molecule

—

INHIBITOR

—

Curated

NPM1 has variant …HAS_VARIANTderived30 of 30show fewer
→ has variant	EXON 11 MUTATION 29 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	29	Curated	civic	graph →
→ has variant	MUTATIONother 3 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia with NPM1 Mutation	3	Curated	civic	graph →
→ has variant	W288FSindel 3 accepted CIViC evidence items	—	—	Acute Myeloid Leukemia	3	Curated	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*101T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*1deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*29A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*2A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*33T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.353-107T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.525-39A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.543T>C (p.Phe181=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.641C>A (p.Ser214Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*73T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*75C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*76T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*80T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*81A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.847-5T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.847-6_847-5deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.863_864insCAGG (p.Trp288fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.863_864insCATG (p.Trp288fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.863_864insCCTG (p.Trp288fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.863_864insCGTG (p.Trp288fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.864_873delinsTTTAAGGATTCGTC (p.Trp288fs)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.869_874delinsCCTTCGCTTC (p.Trp290fs)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.869_875delinsCCCTGGCTAGG (p.Trp290fs)indel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.875del (p.Lys292fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.885A>G (p.Ter295=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002520.7(NPM1):c.*98C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NR_149149.2(NPM1):n.858_859deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

NPM1 altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Acute Myeloid Leukemiahematologic_malignancy 233 / 903 cases (26 %) · ssm · aml_ohsu_2022 · largest of 7 cohorts	—	—	Acute Myeloid Leukemia	7	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndrome 674 / 4,231 cases (16 %) · ssm · mds_mskcc_2020	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →

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