MSH6

mutS homolog 6

Identifier: CI-GENE-00015163
Entity page: /gene/MSH6 ↗
Edges: 10,236

Neighbours: 5 cancers15 variants
Drawn: 20 of 20 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MSH6 associated with …ASSOCIATED_WITH3 of 3
→ associated with	Malignant Colorectal Neoplasmsubtype 4 source records aggregated	supports	C	Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ associated with	Malignant Endometrial Neoplasmsubtype	supports

MSH6 has variant …HAS_VARIANTderived15 of 10,231show all (up to 200)
→ has variant	I891FSindel 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	LOSSdeletion_cna 1 accepted CIViC evidence items	—	—	Transitional Cell Carcinoma	1	Curated	civic	graph →
→ has variant	P138TSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	R1242CSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	R1242HSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	V352ISNV 1 accepted CIViC evidence items	—	—	Malignant Endometrial Neoplasm	1	Curated	civic	graph →
→ has variant	I972FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	MHS6:c.3647-65_3647-61deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	MSH6:c.3647-51_3647-35del17other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000002.11:g.(?_48010221)_(48010632_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000002.11:g.(?_48010221)_(48032166_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000002.11:g.(?_48010363)_(48010642_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000002.11:g.(?_48010363)_(48018272_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000002.11:g.(?_48010363)_(48034009_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000002.11:g.(?_48010367)_(48034005_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

MSH6 has variant …HAS_VARIANTderived15 of 10,231show all (up to 200)

→ has variant

I891FSindel

1 accepted CIViC evidence items

—

Malignant Colorectal Neoplasm

Curated

MSH6 altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Endometrial Carcinoma 75 / 511 cases (15 %) · ssm · ucec_tcga_gdc · largest of 2 cohorts	—	—	Endometrial Carcinoma	2	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 33 / 527 cases (6.3 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths