MSH6 V352I

CI-VAR-00004520Explore in graph →NP_000170.1:p.Val352IleNM_000179.2:c.1054G>AClinVar 182617 CIViC 775 rs730881787

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Endometrial Neoplasm1
MSH6 V352I	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	accepted	EID1839 This variant (V352I), identified in a case of microsatellite-unstable endometrial cancer, was confirmed to be somatic in a 69 year-old female patient with suspected Lynch Syndrome (LS). The patient wa… (full text at CIViC) PMID 25111426 · Geurts-Giele et al., 2014 · Open in CIViC	civic

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
182617	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Hereditary cancer-predisposing syndrome; Lynch syndrome 5; Hereditary nonpolyposis colorectal neoplasms; Hereditary nonpolyposis colon cancer; MSH6-related disorder; Hereditary breast ovarian cancer syndrome; Lynch syndrome	germline	15	Jan 13, 2026