MDM2

MDM2 proto-oncogene

Identifier: CI-GENE-00012270
Entity page: /gene/MDM2 ↗
Edges: 186

Neighbours: 4 cancers15 variants1 drugs
Drawn: 20 of 20 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
MDM2 associated with …ASSOCIATED_WITH3 of 3
→ associated with	Pleural Malignant Mesotheliomasubtype 2 source records aggregated	supports	B	Pleural Malignant Mesothelioma	2	Curated	civic	graph →
→ associated with	Esophageal Squamous Cell Carcinomasubtype	supports

MDM2 targets …TARGETS1 of 1
← targets	Navtemadlinsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

MDM2 targets …TARGETS1 of 1

← targets

Navtemadlinsmall_molecule

—

INHIBITOR

—

Curated

MDM2 has variant …HAS_VARIANTderived15 of 181show all (up to 200)
→ has variant	EXPRESSIONexpression 2 accepted CIViC evidence items	—	—	Pleural Malignant Mesothelioma	2	Curated	civic	graph →
→ has variant	RS34886328 1 accepted CIViC evidence items	—	—	Esophageal Squamous Cell Carcinoma	1	Curated	civic	graph →
→ has variant	SNP309 1 accepted CIViC evidence items	—	—	Malignant Head and Neck Neoplasm	1	Curated	civic	graph →
→ has variant	Amplificationamplification no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000012.12:g.68808017C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.100-10C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.1002T>A (p.Asn334Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.1002T>C (p.Asn334=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.100-5T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.1011T>A (p.Pro337=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.1022G>A (p.Gly341Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.1030A>G (p.Lys344Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.1039A>G (p.Ile347Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.1061A>G (p.Glu354Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002392.6(MDM2):c.1079A>G (p.Glu360Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

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