LYN

LYN proto-oncogene, Src family tyrosine kinase

Identifier: CI-GENE-00011728
Entity page: /gene/LYN ↗
Edges: 13

Neighbours: 3 cancers7 variants3 drugs
Drawn: 13 of 13 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
LYN associated with …ASSOCIATED_WITH2 of 2
→ associated with	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Likehematologic_malignancy 3 source records aggregated	supports	C	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	3	Curated	civic	graph →
→ associated with	Chronic Myeloid Leukemia, BCR-ABL1 Positive

LYN targets …TARGETS3 of 3
← targets	Dasatinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Bosutinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Bafetinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

LYN targets …TARGETS3 of 3

← targets

Dasatinibsmall_molecule

—

INHIBITOR

—

Curated

chembl

graph →

← targets

Bosutinibsmall_molecule

—

INHIBITOR

—

Curated

chembl

graph →

← targets

Bafetinibsmall_molecule

—

INHIBITOR

—

Curated

chembl

graph →

LYN has variant …HAS_VARIANTderived7 of 7
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	3	Curated	civic	graph →
→ has variant	OVEREXPRESSIONexpression 2 accepted CIViC evidence items	—	—	Chronic Myeloid Leukemia, BCR-ABL1 Positive	2	Curated	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Fusionfusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_002350.4(LYN):c.1229C>T (p.Thr410Met)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Y508FSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

LYN has variant …HAS_VARIANTderived7 of 7

→ has variant

Fusionfusion

3 accepted CIViC evidence items

—

B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like

Curated

civic

graph →

→ has variant

OVEREXPRESSIONexpression

2 accepted CIViC evidence items