JAK3

Janus kinase 3

Identifier: CI-GENE-00006503
Entity page: /gene/JAK3 ↗
Edges: 28

Neighbours: 2 cancers24 variants2 drugs
Drawn: 28 of 28 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
JAK3 targets …TARGETS2 of 2
← targets	Tofacitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ruxolitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl

JAK3 has variant …HAS_VARIANTderived24 of 24show fewer
→ has variant	A572VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	E183GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	L156PSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	M511ISNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.1108G>A (p.Glu370Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.1254+20G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.1398G>T (p.Gly466=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.1710G>A (p.Leu570=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.172G>T (p.Ala58Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.1765G>A (p.Gly589Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.1787-15C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.2141C>T (p.Thr714Met)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.2350G>A (p.Asp784Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.2717C>A (p.Pro906His)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.297G>C (p.Leu99=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.308+2T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.309-113C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.3207+101C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.3208G>T (p.Val1070Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000215.4(JAK3):c.*654A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	R172QSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	S61CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	V674ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	V722ISNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →

JAK3 altered in cohorts of …ALTERED_INderived2 of 2
→ altered in cohorts of	Skin Basal Cell Carcinoma 51 / 293 cases (17 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 44 / 696 cases (6.3 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →

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