JAK2

Janus kinase 2

Identifier: CI-GENE-00006502
Entity page: /gene/JAK2 ↗
Edges: 64

Neighbours: 13 cancers41 variants6 drugs
Drawn: 60 of 60 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
JAK2 associated with …ASSOCIATED_WITH12 of 12
→ associated with	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Likehematologic_malignancy 2 source records aggregated	supports	A	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	2	Curated	civic	graph →
→ associated with	Hematopoietic and Lymphoid Cell Neoplasm

JAK2 targets …TARGETS6 of 6
← targets	Tofacitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ruxolitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pacritinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Momelotinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Lestaurtinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Fedratinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

JAK2 targets …TARGETS6 of 6

← targets

Tofacitinibsmall_molecule

—

INHIBITOR

—

Curated

JAK2 has variant …HAS_VARIANTderived41 of 41show fewer
→ has variant	V617FSNV 6 accepted CIViC evidence items	—	—	Malignant Bone Marrow Neoplasm,Lymphoid Leukemia,Chronic Myeloid Leukemia, BCR-ABL1 Positive+1	6	Curated	civic	graph →
→ has variant	Fusionfusion 4 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	4	Curated	civic	graph →
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	3	Curated	civic	graph →
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	3	Curated	civic	graph →
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	3	Curated	civic	graph →
→ has variant	Fusionfusion 3 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	3	Curated	civic	graph →
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	2	Curated	civic	graph →
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	Hematopoietic and Lymphoid Cell Neoplasm,B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	2	Curated	civic	graph →
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	2	Curated	civic	graph →
→ has variant	Fusionfusion 2 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	2	Curated	civic	graph →
→ has variant	c.1641+1dup 1 accepted CIViC evidence items	—	—	Cutaneous Melanoma	1	Curated	civic	graph →
→ has variant	F694LSNV 1 accepted CIViC evidence items	—	—	B Acute Lymphoblastic Leukemia	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	B Lymphoblastic Leukemia/Lymphoma, BCR-ABL1-Like	1	Curated	civic	graph →
→ has variant	Splice Site (c.1641+2T>G)splice 1 accepted CIViC evidence items	—	—	Melanoma	1	Curated	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.1711G>A (p.Gly571Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.1759C>A (p.His587Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.176C>G (p.Ser59Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.1821G>C (p.Lys607Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.2048G>C (p.Arg683Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.2049A>T (p.Arg683Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.226+1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.2385G>T (p.Arg795Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.2571+5A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.2599C>T (p.Arg867Trp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.2798C>A (p.Pro933Gln)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.289C>G (p.Pro97Ala)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.3060-72A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_004972.4(JAK2):c.3177G>A (p.Ala1059=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Overexpressionexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	R683GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

JAK2 altered in cohorts of …ALTERED_INderived5 of 5
→ altered in cohorts of	Myeloproliferative Neoplasm 112 / 151 cases (74 %) · ssm · mpn_cimr_2013	—	—	Myeloproliferative Neoplasm	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanomacancer 325 / 470 cases (69 %) · ssm · TCGA-SKCM	—	—	Cutaneous Melanoma	1	Observed	gdc	graph →
→ altered in cohorts of	Acute Lymphoblastic Leukemia 66 / 768 cases (8.6 %) · ssm · TARGET-ALL-P2	—	—	Acute Lymphoblastic Leukemia	1	Observed	gdc	graph →
→ altered in cohorts of	Myelodysplastic Syndrome 336 / 4,231 cases (7.9 %) · ssm · mds_mskcc_2020	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 29 / 527 cases (5.5 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

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