IGF1R

insulin like growth factor 1 receptor

Identifier: CI-GENE-00005488
Entity page: /gene/IGF1R ↗
Edges: 20

Neighbours: 4 cancers11 variants5 drugs
Drawn: 20 of 20 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Edges

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
IGF1R associated with …ASSOCIATED_WITH3 of 3
→ associated with	Sarcomacancer_family	supports	B	Sarcoma	1	Curated	civic	graph →
→ associated with	Malignant Breast Neoplasmcancer_family	supports	B

IGF1R targets …TARGETS5 of 5
← targets	Teprotumumabmonoclonal_antibody	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	NVP-AEW541small_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Linsitinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ganitumabmonoclonal_antibody	—	ANTAGONIST	—	1	Curated	chembl	graph →
← targets	Cixutumumabmonoclonal_antibody	—	ANTAGONIST	—	1	Curated	chembl	graph →

IGF1R targets …TARGETS5 of 5

← targets

Teprotumumabmonoclonal_antibody

—

ANTAGONIST

—

Curated

IGF1R has variant …HAS_VARIANTderived11 of 11
→ has variant	EXPRESSIONexpression 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	NUCLEAR EXPRESSIONexpression 1 accepted CIViC evidence items	—	—	Sarcoma	1	Curated	civic	graph →
→ has variant	Overexpressionexpression 1 accepted CIViC evidence items	—	—	Malignant Breast Neoplasm	1	Curated	civic	graph →
→ has variant	NM_000875.5(IGF1R):c.100G>C (p.Gly34Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000875.5(IGF1R):c.1463-5C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000875.5(IGF1R):c.1589+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000875.5(IGF1R):c.2202-16T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000875.5(IGF1R):c.3298-9C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000875.5(IGF1R):c.3722+5G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000875.5(IGF1R):c.903C>T (p.Gly301=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000875.5(IGF1R):c.928G>A (p.Gly310Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

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