FLT4

fms related receptor tyrosine kinase 4

Identifier: CI-GENE-00002046
Entity page: /gene/FLT4 ↗
Edges: 54

Neighbours: 5 cancers30 variants15 drugs
Drawn: 50 of 50 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FLT4 targets …TARGETS15 of 19show all (up to 200)
← targets	Vatalanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Vandetanibsmall_molecule	—	INHIBITOR	—	1	Curated

FLT4 has variant …HAS_VARIANTderived30 of 30show fewer
→ has variant	Amplificationamplification no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.1198G>A (p.Ala400Thr)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.156-209G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.1921C>T (p.Pro641Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2104G>T (p.Ala702Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2168-28A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2407-6C>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2407-7C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2414A>C (p.His805Pro)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2433C>A (p.Gly811=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2470C>A (p.Leu824Met)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2496C>G (p.Ser832=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2498A>C (p.Tyr833Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2502T>A (p.Asp834Glu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2507G>A (p.Ser836Asn)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2519del (p.Phe840fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2542+12A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2542+18deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2542+20deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2647+31deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.2860C>T (p.Pro954Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.3002-9A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.3056del (p.Phe1019fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.3064del (p.Ala1022fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.3065C>T (p.Ala1022Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.3072del (p.Met1025fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.3076del (p.Glu1026fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.3712G>A (p.Gly1238Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_182925.5(FLT4):c.3867C>T (p.Ser1289=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →

FLT4 has variant …HAS_VARIANTderived30 of 30show fewer

→ has variant

Amplificationamplification

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

FLT4 altered in cohorts of …ALTERED_INderived5 of 5
→ altered in cohorts of	Endometrial Carcinoma 36 / 181 cases (20 %) · ssm · ucec_ccr_msk_2022	—	—	Endometrial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 90 / 696 cases (13 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 23 / 322 cases (7.1 %) · ssm · bm_nsclc_mskcc_2023	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Rectal Adenocarcinoma 432 / 7,237 cases (6.0 %) · ssm · crc_msk_2026	—	—	Rectal Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 28 / 527 cases (5.3 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

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