FLT1

fms related receptor tyrosine kinase 1

Identifier: CI-GENE-00002042
Entity page: /gene/FLT1 ↗
Edges: 41

Neighbours: 3 cancers19 variants15 drugs
Drawn: 37 of 37 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
FLT1 targets …TARGETS15 of 19show all (up to 200)
← targets	Vatalanibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Vandetanibsmall_molecule	—	INHIBITOR	—	1	Curated

FLT1 has variant …HAS_VARIANTderived19 of 19show fewer
→ has variant	Mutationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.1106+219G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.162G>C (p.Arg54Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.2439_2466del (p.Tyr815fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.2594-52G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.2654_2655insA (p.Gly886fs)insertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.2708-190C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.2708-195G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.2708-29A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.2708-39G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.3174+225T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.3175-69A>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.3204T>C (p.Pro1068=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.3287-16A>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.3329G>C (p.Cys1110Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.3721-78C>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.3815+159A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.513+216C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_002019.4(FLT1):c.64+22G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →

FLT1 altered in cohorts of …ALTERED_INderived3 of 3
→ altered in cohorts of	Cutaneous Melanoma 111 / 696 cases (16 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 20 / 181 cases (11 %) · ssm · ucec_ccr_msk_2022	—	—	Endometrial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 32 / 527 cases (6.1 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

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