ERCC1

ERCC excision repair 1, endonuclease non-catalytic subunit

Identifier: CI-GENE-00044915
Entity page: /gene/ERCC1 ↗
Edges: 9

Neighbours: 3 cancers6 variants
Drawn: 9 of 9 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ERCC1 associated with …ASSOCIATED_WITH3 of 3
→ associated with	Bladder Carcinomasubtype	supports	B	Bladder Carcinoma	1	Curated	civic	graph →
→ associated with	Ovarian Carcinomasubtype	supports	B

ERCC1 has variant …HAS_VARIANTderived6 of 6
→ has variant	Expressionexpression 2 accepted CIViC evidence items	—	—	Bladder Carcinoma	2	Curated	civic	graph →
→ has variant	Underexpressionexpression 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Ovarian Carcinoma	2	Curated	civic	graph →
→ has variant	NM_001983.4(ERCC1):c.106-3C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001983.4(ERCC1):c.425+86A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001983.4(ERCC1):c.-8+1G>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Overexpressionexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

ERCC1 has variant …HAS_VARIANTderived6 of 6

→ has variant

Expressionexpression

2 accepted CIViC evidence items

—

Bladder Carcinoma

Curated

civic

graph →

→ has variant

Underexpressionexpression

2 accepted CIViC evidence items