DICER1

dicer 1, ribonuclease III

Identifier: CI-GENE-00043379
Entity page: /gene/DICER1 ↗
Edges: 7,504

Neighbours: 7 cancers15 variants
Drawn: 22 of 22 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
DICER1 associated with …ASSOCIATED_WITH4 of 4
→ associated with	Ovarian Sertoli-Leydig Cell Tumorsubtype 2 source records aggregated	supports	B	Ovarian Sertoli-Leydig Cell Tumor	2	Curated	civic	graph →
→ associated with	Ovarian Sertoli-Leydig Cell Tumorsubtype

DICER1 has variant …HAS_VARIANTderived15 of 7,496show all (up to 200)
→ has variant	D1709NSNV 3 accepted CIViC evidence items	—	—	Ovarian Sertoli-Leydig Cell Tumor	3	Curated	civic	graph →
→ has variant	D1709ESNV 2 accepted CIViC evidence items	—	—	Ovarian Sertoli-Leydig Cell Tumor	2	Curated	civic	graph →
→ has variant	D1709GSNV 2 accepted CIViC evidence items	—	—	Granulosa Cell Tumor,Ovarian Sertoli-Leydig Cell Tumor	2	Curated	civic	graph →
→ has variant	E1705KSNV 2 accepted CIViC evidence items	—	—	Ovarian Gynandroblastoma,Ovarian Sertoli-Leydig Cell Tumor	2	Curated	civic	graph →
→ has variant	E1813QSNV 2 accepted CIViC evidence items	—	—	Ovarian Sertoli-Leydig Cell Tumor	2	Curated	civic	graph →
→ has variant	D1810HSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D1810NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D1810YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E1813DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E1813GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E1813KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E1813 mutations no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	G1809RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Loss-of-function no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NC_000014.8:g.(?_95552565)_(95599840_?)dupinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

DICER1 altered in cohorts of …ALTERED_INderived4 of 4
→ altered in cohorts of	Endometrial Carcinoma 69 / 511 cases (14 %) · ssm · ucec_tcga_gdc · largest of 4 cohorts	—	—	Endometrial Carcinoma	4	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 27 / 247 cases (11 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 52 / 696 cases (7.5 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 31 / 527 cases (5.9 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

Radial view

Every edge, grouped by relationship

Paths