DHFR

dihydrofolate reductase

Identifier: CI-GENE-00043321
Entity page: /gene/DHFR ↗
Edges: 6

Neighbours: 3 variants3 drugs
Drawn: 6 of 6 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
DHFR targets …TARGETS3 of 3
← targets	Pralatrexatesmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pemetrexedsmall_molecule	—	INHIBITOR	—	1	Curated	chembl

DHFR has variant …HAS_VARIANTderived3 of 3
→ has variant	Decreased RNA expressionexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000791.4(DHFR):c.-204T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →
→ has variant	NM_000791.4(DHFR):c.99A>G (p.Arg33=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	Observed	civic	graph →

DHFR has variant …HAS_VARIANTderived3 of 3

→ has variant

Decreased RNA expressionexpression

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

civic

graph →

→ has variant

NM_000791.4(DHFR):c.-204T>ASNV

no accepted CIViC evidence item (variant record only)