Variant · Expression
DHFR Decreased RNA expression
CI-VAR-00417096Explore in graph →CIViC 5585
Curated evidence
Evidence by cancer (1 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-26
- Retrieved
- Sep 26, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 21449674
- Run
- ING-CIVIC-20260926-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Malignant Colorectal Neoplasm1 | ||||||||
| DHFR Decreased RNA expression | Fluorouracil | Predictive | D | Supports Sensitivity Response | 4 | submitted | EID13310In HCT-116, HT-29, and SW620 colorectal cancer cells, shRNA-mediated reduction of DHFR expression significantly increased sensitivity to fluorouracil, as measured by decreased IC50. DHFR and GGH knock… (full text at CIViC) PMID 21449674 · Muhale et al., 2011 · Open in CIViC | civic |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available
No ClinVar interpretation attached to this variant.