CRBN

cereblon

Identifier: CI-GENE-00042190
Entity page: /gene/CRBN ↗
Edges: 8

Neighbours: 1 cancers4 variants3 drugs
Drawn: 8 of 8 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
CRBN associated with …ASSOCIATED_WITH1 of 1
→ associated with	Multiple Myelomahematologic_malignancy	supports	C	Multiple Myeloma	1	Curated	civic	graph →
CRBN targets …TARGETS3 of 3
← targets

CRBN has variant …HAS_VARIANTderived4 of 4
→ has variant	Mutationother 1 accepted CIViC evidence items	—	—	Multiple Myeloma	1	Curated	civic	graph →
→ has variant	High expressionexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_016302.4(CRBN):c.1100A>T (p.Asn367Ile)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_016302.4(CRBN):c.175-5T>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

CRBN has variant …HAS_VARIANTderived4 of 4

→ has variant

Mutationother

1 accepted CIViC evidence items

—

Multiple Myeloma

Curated

civic

graph →

→ has variant

High expressionexpression

no accepted CIViC evidence item (variant record only)