CHEK1

checkpoint kinase 1

Identifier: CI-GENE-00041223
Entity page: /gene/CHEK1 ↗
Edges: 11

Neighbours: 2 cancers8 variants1 drugs
Drawn: 11 of 11 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
CHEK1 associated with …ASSOCIATED_WITH2 of 2
→ associated with	Castration-Resistant Prostate Carcinomasubtype	supports	A	Castration-Resistant Prostate Carcinoma	1	Curated	civic	graph →
→ associated with	Lung Small Cell Carcinomasubtype	supports

CHEK1 targets …TARGETS1 of 1
← targets	Prexasertibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

CHEK1 targets …TARGETS1 of 1

← targets

Prexasertibsmall_molecule

—

INHIBITOR

—

Curated

chembl

graph →

CHEK1 has variant …HAS_VARIANTderived8 of 8
→ has variant	Mutationother 1 accepted CIViC evidence items	—	—	Castration-Resistant Prostate Carcinoma	1	Curated	civic	graph →
→ has variant	Overexpressionexpression 1 accepted CIViC evidence items	—	—	Lung Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	NM_001114122.3(CHEK1):c.1135C>T (p.Arg379Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001114122.3(CHEK1):c.1234-26G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001114122.3(CHEK1):c.1336-481T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001114122.3(CHEK1):c.289+83T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001114122.3(CHEK1):c.290-173C>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001114122.3(CHEK1):c.478C>T (p.Arg160Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

CHEK1 has variant …HAS_VARIANTderived8 of 8

→ has variant

Mutationother

1 accepted CIViC evidence items

—

Castration-Resistant Prostate Carcinoma

Curated

civic

graph →

→ has variant

Overexpressionexpression

1 accepted CIViC evidence items