BTK

Bruton tyrosine kinase

Identifier: CI-GENE-00022179
Entity page: /gene/BTK ↗
Edges: 37

Neighbours: 2 cancers30 variants4 drugs
Drawn: 36 of 36 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
BTK associated with …ASSOCIATED_WITH2 of 2
→ associated with	Chronic Lymphocytic Leukemiahematologic_malignancy 3 source records aggregated	supports	B	Chronic Lymphocytic Leukemia	3	Curated	civic	graph →
→ associated with	Chronic Lymphocytic Leukemiahematologic_malignancy	supports

BTK targets …TARGETS4 of 4
← targets	Zanubrutinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Pirtobrutinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Ibrutinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →
← targets	Acalabrutinibsmall_molecule	—	INHIBITOR	—	1	Curated	chembl	graph →

BTK targets …TARGETS4 of 4

← targets

Zanubrutinibsmall_molecule

—

INHIBITOR

—

Curated

BTK has variant …HAS_VARIANTderived30 of 30show fewer
→ has variant	C481SSNV 2 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	2	Curated	civic	graph →
→ has variant	MUTATIONother 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	T316ASNV 1 accepted CIViC evidence items	—	—	Chronic Lymphocytic Leukemia	1	Curated	civic	graph →
→ has variant	C481RSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C481YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Expressionexpression no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1102G>T (p.Gly368Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1103-17CT[4]other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1103-2A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1278C>T (p.Asp426=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1349+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1349+6T>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1442G>C (p.Cys481Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1621G>T (p.Gly541Cys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1630A>G (p.Arg544Gly)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1631+2T>CSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1633T>G (p.Tyr545Asp)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1765G>T (p.Glu589Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1908+5G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.1909-2A>GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.240G>A (p.Pro80=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.309+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.397C>A (p.Arg133=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.586C>T (p.Gln196Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.588+1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.777-1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.895-1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.905G>T (p.Gly302Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.974+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000061.3(BTK):c.974+1G>TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

Radial view

Every edge, grouped by relationship

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