BCOR

BCL6 corepressor

Identifier: CI-GENE-00021727
Entity page: /gene/BCOR ↗
Edges: 46

Neighbours: 13 cancers15 variants
Drawn: 28 of 28 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

Radial view

Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
BCOR associated with …ASSOCIATED_WITH4 of 4
→ associated with	Central Nervous System Tumor with BCOR Internal Tandem Duplicationmolecular_subtype 4 source records aggregated	supports	B	Central Nervous System Tumor with BCOR Internal Tandem Duplication	4	Curated	civic	graph →
→ associated with

BCOR has variant …HAS_VARIANTderived15 of 33show all (up to 200)
→ has variant	ITDinsertion 9 accepted CIViC evidence items	—	—	Sarcoma,Central Nervous System Tumor with BCOR Internal Tandem Duplication,Clear Cell Sarcoma of the Kidney	9	Curated	civic	graph →
→ has variant	Mutationother 1 accepted CIViC evidence items	—	—	Malignant Gastric Neoplasm	1	Curated	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.1176del (p.Lys392fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.1381A>G (p.Met461Val)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.1629_1644del (p.Cys544fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.1863_1885del (p.Asn621fs)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.2265C>G (p.Tyr755Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.2429G>T (p.Arg810Leu)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.2572G>T (p.Glu858Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.3051+1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.3052-13G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.3801C>G (p.Asn1267Lys)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.3813G>A (p.Ser1271=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.3865G>A (p.Gly1289Ser)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_001123385.2(BCOR):c.3883_3884del (p.Leu1296fs)other no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

BCOR has variant …HAS_VARIANTderived15 of 33show all (up to 200)

→ has variant

ITDinsertion

9 accepted CIViC evidence items

—

Sarcoma,Central Nervous System Tumor with BCOR Internal Tandem Duplication,Clear Cell Sarcoma of the Kidney

Curated

BCOR altered in cohorts of …ALTERED_INderived9 of 9
→ altered in cohorts of	Skin Basal Cell Carcinoma 55 / 293 cases (19 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 34 / 247 cases (14 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Adenoid Cystic Carcinoma 109 / 1,049 cases (10 %) · ssm · acc_2019	—	—	Adenoid Cystic Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 184 / 1,882 cases (9.8 %) · ssm · ucec_ancestry_cds_msk_2023 · largest of 7 cohorts	—	—	Endometrial Carcinoma	7	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 53 / 696 cases (7.6 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Myelodysplastic Syndrome 220 / 3,323 cases (6.6 %) · ssm · mds_iwg_2022	—	—	Myelodysplastic Syndrome	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 34 / 527 cases (6.5 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 20 / 322 cases (6.2 %) · ssm · bm_nsclc_mskcc_2023	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Acute Myeloid Leukemia 48 / 903 cases (5.3 %) · ssm · aml_ohsu_2022 · largest of 2 cohorts	—	—	Acute Myeloid Leukemia	2	Observed	cbioportal	graph →

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