ATRX

ATRX chromatin remodeler

Identifier: CI-GENE-00021460
Entity page: /gene/ATRX ↗
Edges: 100

Neighbours: 16 cancers15 variants
Drawn: 31 of 31 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

Neighbourhood

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

Edges

Every edge, grouped by relationship

Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
ATRX associated with …ASSOCIATED_WITH4 of 4
→ associated with	Anaplastic Astrocytomasubtype 2 source records aggregated	supports	B	Anaplastic Astrocytoma	2	Curated	civic	graph →
→ associated with	Childhood Low Grade Gliomasubtype	supports	B

ATRX has variant …HAS_VARIANTderived15 of 84show all (up to 200)
→ has variant	Underexpressionexpression 3 accepted CIViC evidence items	—	—	Anaplastic Astrocytoma,Glioblastoma,Childhood Low Grade Glioma	3	Curated	civic	graph →
→ has variant	Deletiondeletion 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Mutationother 1 accepted CIViC evidence items	—	—	Anaplastic Astrocytoma	1	Curated	civic	graph →
→ has variant	DELETIONdeletion_cna no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Loss-of-function no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.1252C>T (p.Arg418Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.1363A>T (p.Lys455Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.1373C>A (p.Ser458Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.1512T>G (p.Tyr504Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.1558G>T (p.Val520Phe)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.1727C>G (p.Ser576Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.1847A>G (p.Lys616Arg)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.1871T>A (p.Leu624Ter)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.189G>A (p.Glu63=)SNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	NM_000489.6(ATRX):c.190-1G>ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

ATRX has variant …HAS_VARIANTderived15 of 84show all (up to 200)

→ has variant

Underexpressionexpression

3 accepted CIViC evidence items

—

Anaplastic Astrocytoma,Glioblastoma,Childhood Low Grade Glioma

Curated

ATRX altered in cohorts of …ALTERED_INderived12 of 12
→ altered in cohorts of	Uterine Corpus Sarcoma 25 / 108 cases (23 %) · ssm · usarc_msk_2020	—	—	Uterine Corpus Sarcoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 222 / 1,004 cases (22 %) · ssm · glioma_mskcc_2019 · largest of 12 cohorts	—	—	Diffuse Glioma	12	Observed	cbioportal	graph →
→ altered in cohorts of	Pancreatic Neuroendocrine Tumor 21 / 96 cases (22 %) · ssm · panet_msk_2018	—	—	Pancreatic Neuroendocrine Tumor	1	Observed	cbioportal	graph →
→ altered in cohorts of	Skin Basal Cell Carcinoma 64 / 293 cases (22 %) · ssm · bcc_unige_2016	—	—	Skin Basal Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Carcinoma 77 / 517 cases (15 %) · ssm · ucec_tcga_pan_can_atlas_2018 · largest of 5 cohorts	—	—	Endometrial Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Endometrial Endometrioid Adenocarcinoma 29 / 247 cases (12 %) · ssm · uec_cptac_gdc	—	—	Endometrial Endometrioid Adenocarcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 61 / 527 cases (12 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 78 / 696 cases (11 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Neuroblastoma 24 / 223 cases (11 %) · ssm · nbl_msk_2023	—	—	Neuroblastoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinoma 20 / 322 cases (6.2 %) · ssm · bm_nsclc_mskcc_2023	—	—	Lung Non-Small Cell Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Bladder Urothelial Carcinoma 25 / 412 cases (6.1 %) · ssm · blca_tcga_pub_2017	—	—	Bladder Urothelial Carcinoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Adenocarcinoma 139 / 2,653 cases (5.2 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 2 cohorts	—	—	Lung Adenocarcinoma	2	Observed	cbioportal	graph →

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