Vistusertib

small molecule

Identifier: CI-DRUG-00000641
Entity page: /drug/vistusertib ↗
Edges: 74

Neighbours: 23 cancers1 genes10 trials
Drawn: 34 of 34 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Vistusertib targets …TARGETS1 of 1
→ targets	MTOR	—	INHIBITOR	—	1	Curated	chembl	graph →
Vistusertib investigated for …INVESTIGATED_FOR15 of 16show all (up to 200)
→ investigated for	Meningiomasubtype	unknown

Vistusertib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 28show all (up to 200)
→ investigated in trials for	Solid Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Diffuse Large B-Cell Lymphoma 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Diffuse Large B-Cell Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinomasubtype 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Small Cell Carcinomasubtype 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Small Cell Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Breast Neoplasm 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Breast Neoplasm	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Meningiomasubtype 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Meningioma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Triple-Negative Breast Carcinomamolecular_subtype 2 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Triple-Negative Breast Carcinoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Adenocarcinomahistology 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Carcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Breast Neoplasmcancer_family 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Childhood Malignant Neoplasm 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Childhood Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Endometrial Adenocarcinoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Endometrial Adenocarcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Endometrial Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Endometrial Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Endometrial Neoplasmsubtype 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Endometrial Neoplasm	1	Observed	clinicaltrials	graph →

Vistusertib investigated in trials for …INVESTIGATED_IN_TRIALSderived15 of 28show all (up to 200)

→ investigated in trials for

Solid Neoplasm

3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)

—

Solid Neoplasm

Observed

Vistusertib studied in …STUDIED_INderived10 of 29show all (up to 200)
→ studied in	NCT02208375Phase 1 · active not recruiting mTORC1/2 Inhibitor AZD2014 or the Oral AKT Inhibitor AZD5363 for Recurrent Endometrial and Ovarian · 29 trials list this drug (6 active)	—	—	Breast Carcinoma,Primary Peritoneal Carcinoma,Ovarian Carcinoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT02813135Phase 1/Phase 2 · recruiting European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors · 29 trials list this drug (6 active)	—	—	Childhood Malignant Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02664935Phase 2 · completed National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung Cancer · 29 trials list this drug (6 active)	—	—	Adenocarcinoma,Squamous Cell Carcinoma,Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01597388Phase 1 · completed AZD2014 and Fulvestrant in Patients With ER+ Advanced Metastatic Breast Cancer · 29 trials list this drug (6 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02546661Phase 1 · active not recruiting Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer · 29 trials list this drug (6 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT03334617Phase 2 · active not recruiting Phase II Umbrella Study of Novel Anti-cancer Agents in Participants With NSCLC Who Progressed on an Anti-PD-1/PD-L1 Containing Therapy · 29 trials list this drug (6 active)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02299999Phase 2 · active not recruiting SAFIR02_Breast - Efficacy of Genome Analysis as a Therapeutic Decision Tool for Patients With Metastatic Breast Cancer · 29 trials list this drug (6 active)	—	—	Malignant Breast Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02398747Phase 1 · completed Japanese Phase I Study of AZD2014 in Advanced Solid Malignancies · 29 trials list this drug (6 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT02216786Phase 2 · completed A Randomized Study of AZD2014 in Combination With Fulvestrant in Metastatic or Advanced Breast Cancer · 29 trials list this drug (6 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT02599714Phase 1 · completed Study of AZD2014 and Palbociclib in Patients With Estrogen Receptor Positive (ER+) Metastatic Breast Cancer · 29 trials list this drug (6 active)	—	—	Breast Neoplasm	1	Observed	clinicaltrials	graph →

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