Quisinostat

small molecule

Identifier: CI-DRUG-00000494
Entity page: /drug/quisinostat ↗
Edges: 29

Neighbours: 10 cancers11 genes7 trials
Drawn: 28 of 28 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Quisinostat targets …TARGETS11 of 11
→ targets	HDAC9	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	HDAC10	—	INHIBITOR	—	1	Curated	chembl

Quisinostat investigated for …INVESTIGATED_FOR3 of 3
→ investigated for	Ovarian Neoplasmsubtype	unknown	2	Ovarian Neoplasm	1	Curated	chembl	graph →
→ investigated for	Primary Cutaneous T-Cell Non-Hodgkin Lymphomahematologic_malignancy	unknown	2	Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	1	Curated	chembl	graph →
→ investigated for	Lymphomacancer_family	unknown	1	Lymphoma	1	Curated	chembl	graph →

Quisinostat investigated for …INVESTIGATED_FOR3 of 3

→ investigated for

Ovarian Neoplasmsubtype

unknown

Ovarian Neoplasm

Curated

Quisinostat investigated in trials for …INVESTIGATED_IN_TRIALSderived8 of 8
→ investigated in trials for	Lymphomacancer_family 2 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	2	Observed	clinicaltrials	graph →
→ investigated in trials for	Leukemia 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Leukemia	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lung Non-Small Cell Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lung Non-Small Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Ovarian Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Ovarian Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Myelodysplastic Syndrome 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Myelodysplastic Syndrome	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Ovarian Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Ovarian Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Uveal Melanoma 1 trials (1 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Uveal Melanoma	1	Observed	clinicaltrials	graph →

Quisinostat studied in …STUDIED_INderived7 of 7
→ studied in	NCT06932757Phase 2 · recruiting Adjuvant Quisinostat in High-Risk Uveal Melanoma · 7 trials list this drug (2 active)	—	—	Uveal Melanoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT06824662early Phase 1 · active not recruiting Phase 0 With Expansion Phase Clinical Trial of Quisinostat Plus Radiotherapy in Newly-diagnosed and Recurrent Grade 4 IDH-Wildtype Glioblastomas · 7 trials list this drug (2 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT02948075Phase 2 · completed Safety and Efficacy of Quisinostat, a Histone Deacetylase Inhibitor, in Combination With Chemotherapy · 7 trials list this drug (2 active)	—	—	Malignant Ovarian Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01486277Phase 2 · completed A Study of the Histone Deacetylase Inhibitor (HDACi) Quisinostat (JNJ-26481585) in Patients With Previously Treated Stage Ib-IVa Cutaneous T-cell Lymphoma · 7 trials list this drug (2 active)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT02728492Phase 1 · completed Safety, Tolerability and Pharmacokinetics of Quisinostat, a Histone Deacetylase Inhibitor, in Combination With Chemotherapy · 7 trials list this drug (2 active)	—	—	Lung Non-Small Cell Carcinoma,Ovarian Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00677105Phase 1 · completed A Safety and Dose-finding Study of JNJ-26481585 for Patients With Advanced Solid Malignancies and Lymphoma. · 7 trials list this drug (2 active)	—	—	Neoplasm,Lymphoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00676728Phase 1 · terminated A Study of the Histone-deacetylase Inhibitor JNJ-26481585 in Patients With Advanced or Refractory Leukemia or Myelodysplastic Syndrome · 7 trials list this drug (2 active)	—	—	Leukemia,Myelodysplastic Syndrome	1	Observed	clinicaltrials	graph →

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