Gene

HDAC6

histone deacetylase 6

Explore in graph →CI-GENE-00004248HGNC:14064 ENSG00000094631 NCBI 10013 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
HDAC6 Overexpression1
Panobinostat + Trichostatin A + Vorinostat	Malignant Esophageal Neoplasm	Predictive	D	Supports Sensitivity Response	2	submitted	EID9856 HDAC expression was assessed from 27 esophageal squamous cell carcinoma (ESCC) cell lines to determine the efficacy of HDAC inhibitors and found that practically all 10 HDAC (HDAC1, HDAC2, HDAC3, HDAC… (full text at CIViC) PMID 30484863 · Cheng et al., 2018 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (1)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Triple-Negative Breast Cancer (FUSCC, Cell Research 2020) brca_fuscc_2020	Invasive Breast Carcinoma	Ssm	3

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.