Patidegib

small molecule

Identifier: CI-DRUG-00000458
Entity page: /drug/patidegib ↗
Edges: 20

Neighbours: 6 cancers1 genes1 variants9 trials
Drawn: 17 of 17 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,149 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Patidegib predicts response to …PREDICTS_RESPONSE_TO1 of 1
← predicts response to	SMO D473HSNV	sensitivity	D	Medulloblastoma	1	Curated	civic	graph →
Patidegib targets …TARGETS1 of 1
→ targets

Patidegib investigated for …INVESTIGATED_FOR5 of 5
→ investigated for	Medulloblastomasubtype	supports	D	Medulloblastoma	1	Curated	civic	graph →
→ investigated for	Chondrosarcomasubtype	unknown	2	Chondrosarcoma	1	Curated	chembl	graph →
→ investigated for	Basal Cell Carcinomahistology	unknown	2	Basal Cell Carcinoma	1	Curated	chembl	graph →
→ investigated for	Neoplasmcancer_family	unknown	1	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Pancreatic Neoplasmsubtype	unknown	1	Pancreatic Neoplasm	1	Curated	chembl	graph →

Patidegib investigated for …INVESTIGATED_FOR5 of 5

→ investigated for

Medulloblastomasubtype

supports

Medulloblastoma

Curated

Patidegib investigated in trials for …INVESTIGATED_IN_TRIALSderived4 of 4
→ investigated in trials for	Basal Cell Carcinomahistology 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Basal Cell Carcinoma	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Bone Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Bone Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Chondrosarcomasubtype 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Chondrosarcoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Neoplasmcancer_family 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →

Patidegib studied in …STUDIED_INderived9 of 9
→ studied in	NCT06050122Phase 3 · completed Efficacy and Safety of Patidegib Gel 2% for Preventing Basal Cell Carcinomas on the Face of Adults With Gorlin Syndrome · 9 trials list this drug (0 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT04155190Phase 2 · terminated A Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas in Patients With Non-Gorlin High Frequency BCC · 9 trials list this drug (0 active)	—	—	Basal Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT04308395Phase 3 · terminated Extension Study of Patidegib Topical Gel, 2% in Subjects With Gorlin Syndrome (Basal Cell Nevus Syndrome) · 9 trials list this drug (0 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT03703310Phase 3 · completed Study of Patidegib Topical Gel, 2%, for the Reduction of Disease Burden of Persistently Developing Basal Cell Carcinomas (BCCs) in Subjects With Basal Cell Nevus Syndrome (Gorlin Syndrome) · 9 trials list this drug (0 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT02762084Phase 2 · completed Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell Carcinomas in Gorlin Syndrome Patients · 9 trials list this drug (0 active)	—	—	not mapped	1	Observed	clinicaltrials	graph →
→ studied in	NCT02828111Phase 2 · completed Clinical Trial of Patidegib Gel 2%, 4%, and Vehicle Applied Once or Twice Daily to Decrease the GLI1 Biomarker in Sporadic Nodular Basal Cell Carcinomas · 9 trials list this drug (0 active)	—	—	Basal Cell Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT01310816Phase 2 · completed A Safety and Efficacy Study of Patients With Metastatic or Locally Advanced (Unresectable) Chondrosarcoma · 9 trials list this drug (0 active)	—	—	Bone Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01609179NA · completed IPI-926 Extension Protocol for Continuation of Treatment With IPI-926 · 9 trials list this drug (0 active)	—	—	Basal Cell Carcinoma,Chondrosarcoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT00761696Phase 1 · completed A Phase 1 Study of IPI-926 in Patients With Advanced and/or Metastatic Solid Tumor Malignancies · 9 trials list this drug (0 active)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →

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