Molibresib

small molecule

Identifier: CI-DRUG-00000384
Entity page: /drug/molibresib ↗
Edges: 25

Neighbours: 10 cancers4 genes9 trials
Drawn: 23 of 23 neighbours (cap 60); table lists every fetched edge

Accepted: cancer:<slug>, gene:<symbol>, variant:<slug>, drug:<slug>, trial:<NCT id>, or a bare CI id. Find slugs with search.

Most connectedLung Non-Small Cell Carcinoma 3,147 Malignant Colorectal Neoplasm 1,866 ABL1 298 EGFR 276 Imatinib 450 Dasatinib 321

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Focus at the centre; neighbours grouped by entity type. Click a node to re-centre the graph on it; ↗ opens the entity page. Hover a spoke for relationship, evidence level, cancer context and source.

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Source-native edges first (aggregated per neighbour, direction, evidence level and source), then derived registry links. Up to 15 per relationship (10 trials); “show all” raises one group to 200.

Relationship	Neighbour	Direction	Evidence level	Cancer context	Support	Claim	Source	Expand
Molibresib targets …TARGETS4 of 4
→ targets	BRD3	—	INHIBITOR	—	1	Curated	chembl	graph →
→ targets	BRD2	—	INHIBITOR	—	1	Curated	chembl

Molibresib investigated for …INVESTIGATED_FOR2 of 2
→ investigated for	Neoplasmcancer_family	unknown	2	Neoplasm	1	Curated	chembl	graph →
→ investigated for	Carcinomacancer_family	unknown	1	Carcinoma	1	Curated	chembl	graph →

Molibresib investigated for …INVESTIGATED_FOR2 of 2

→ investigated for

Neoplasmcancer_family

unknown

Neoplasm

Curated

Molibresib investigated in trials for …INVESTIGATED_IN_TRIALSderived10 of 10
→ investigated in trials for	Neoplasmcancer_family 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	Solid Neoplasm 3 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Solid Neoplasm	3	Observed	clinicaltrials	graph →
→ investigated in trials for	B-Cell Non-Hodgkin Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	B-Cell Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Carcinomacancer_family 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Lymphoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Pancreatic Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Pancreatic Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Malignant Solid Neoplasm 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Malignant Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ investigated in trials for	NUT Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	NUT Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	Pancreatic Carcinoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	Pancreatic Carcinoma	1	Observed	clinicaltrials	graph →
→ investigated in trials for	T-Cell Non-Hodgkin Lymphoma 1 trials (0 active) · conditions mapped to this cancer only (no hierarchy roll-up)	—	—	T-Cell Non-Hodgkin Lymphoma	1	Observed	clinicaltrials	graph →

Molibresib studied in …STUDIED_INderived9 of 9
→ studied in	NCT01943851Phase 2 · completed A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies · 9 trials list this drug (0 active)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02964507Phase 1 · terminated Dose Escalation and Expansion Study of GSK525762 in Combination With Fulvestrant in Participants With Hormone Receptor-positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Advanced or Metastatic Breast Cancer · 9 trials list this drug (0 active)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03150056Phase 1 · terminated Dose Escalation and Dose Expansion Study of GSK525762 in Combination With Androgen Deprivation Therapy in Participants With Castrate-resistant Prostate Cancer · 9 trials list this drug (0 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT02706535Phase 1 · completed A Cross-over Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics (PK) of GSK525762 in Healthy Female Subjects of Non Child Bearing Potential · 9 trials list this drug (0 active)	—	—	Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT03925428Phase 1 · withdrawn Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas · 9 trials list this drug (0 active)	—	—	Lymphoma,Malignant Solid Neoplasm,B-Cell Non-Hodgkin Lymphoma+2	1	Observed	clinicaltrials	graph →
→ studied in	NCT04116359Phase 1/Phase 2 · withdrawn Testing of the Addition of a New Anti-cancer Drug, Molibresib, to Chemotherapy Treatment (Etoposide and Cisplatin) for Patients With NUT Carcinoma · 9 trials list this drug (0 active)	—	—	NUT Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03702036no longer available Compassionate Use Individual Request Program for GSK525762 in NUT Midline Carcinoma · 9 trials list this drug (0 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →
→ studied in	NCT01587703Phase 1 · completed A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers · 9 trials list this drug (0 active)	—	—	Carcinoma	1	Observed	clinicaltrials	graph →
→ studied in	NCT03266159Phase 2 · withdrawn A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Clinical Activity of GSK525762 Plus Trametinib in Subjects With Solid Tumors · 9 trials list this drug (0 active)	—	—	Solid Neoplasm	1	Observed	clinicaltrials	graph →

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